Glutathione

Glutathione is a non-protein tripeptide crucial for immune function. Composed of the aminoacids glutamic acid, cysteine, and glycine, glutathione is present in virtually all body cells, reaching high concentrations in the liver, pancreas, spleen, eyes, heart, brain, and muscle tissues. This compound is one of the most potent and effective antioxidants in neutralizing free radicals. However, natural aging and intense physical exercise reduce glutathione levels, which can be compensated for by exogenous administration, for example, through vials.

Mechanisms of Action and Functions of Glutathione

• Redox Modulation and Antioxidant Protection

Glutathione is a crucial regulator responsible for reducing cysteine levels on the surface of proteins, thereby protecting the body from oxidative damage caused by free radicals. It also plays an essential role in regenerating other antioxidant molecules, such as vitamins C and E, facilitating their recycling and prolonging their antioxidant activity.

• Detoxification and Amino Acid Transport

In addition to its antioxidant function, glutathione is vital for detoxifying toxic compounds, including heavy metals. Its action extends to modulating blood sugar, triglyceride, and cholesterol levels, contributing to metabolic balance.

• Anticarcinogenic Effect

Glutathione possesses anticancer properties by inducing apoptosis in malignant cells while preserving the viability of healthy cells. This mechanism underscores its ability to reduce the risk of developing malignant neoplasms.

• Anti-aging and Dermoprotective Effect

Glutathione plays a crucial role in slowing down cellular aging. It also acts as a skin depigmenting agent by inhibiting the activation of the enzyme tyrosinase, which is responsible for melanin synthesis. By reducing free radicals that can activate tyrosinase, glutathione decreases melanin production, contributing to skin lightening.

Consequences of Deficiency and Preventive Use

Glutathione deficiency can manifest in various pathologies, including coordination problems, hemolysis, leukocyte dysfunction, and nervous tissue deterioration, leading to neurological disorders such as tremors and spasms. This deficiency compromises not only cellular detoxification capacity but also the repair of damage at the DNA, protein, and lipid levels, as well as affecting enzyme regulation and amino acid transport.

Glutathione is essential for mitigating oxidative stress, a chemical reaction triggered by cellular damage caused by viral or bacterial infections, exposure to environmental toxins, medications, heavy metals, or aging. Its preventive use is recommended to promote longevity and maintain cellular integrity, making it ideal for those looking to mitigate the effects of aging and exposure to oxidative stressors.

In conclusion, glutathione supplementation is highly recommended as a preventive and therapeutic intervention, essential for preserving cellular health and longevity.